Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076067 | 0.88 | NOTUM (0.42) | ALOX5NOTUMHTTMAPTTSHR | |
| SCHEMBL23526377 | 0.87 | ALOX5 (0.40) | KMT2AALOX5NOTUMPTGESTP53 | |
| SCHEMBL29945784 | 0.87 | ALOX5 (0.40) | KMT2AALOX5NOTUMPTGESTP53 | |
| SCHEMBL22914551 | 0.86 | NR1H2 (0.50) | ALOX5NR1H2NR1H3PTGESHTT | |
| SCHEMBL23526095 | 0.81 | NOTUM (0.41) | KMT2ANOTUMHTTMAPTTSHR | |
| SCHEMBL24252864 | 0.78 | TSHR (0.46) | KMT2ANOTUMHTTMAPTTSHR | |
| SCHEMBL29570702 | 0.78 | NOTUM (0.42) | NOTUMMAPTTSHRHSD17B10CA12 | |
| SCHEMBL21198962 | 0.78 | NOTUM (0.42) | NOTUMMAPTTSHRHSD17B10CA12 | |
| SCHEMBL517686 | 0.77 | NOTUM (0.47) | NOTUMHTTMAPTTSHRCYP3A4 | |
| SCHEMBL21199629 | 0.77 | NOTUM (0.43) | KMT2ANOTUMMAPTHSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | SOS1, SOS2, SOST | KMT2A 3302/4885ALOX5 4146/4885NR1H2 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.