Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23526377 | 1.00 | ALOX5 (0.40) | ALOX5KMT2ANOTUMGPR35MAPT | |
| SCHEMBL25839669 | 0.87 | KMT2A (0.48) | ALOX5KMT2ANOTUMGPR35MAPT | |
| SCHEMBL20076067 | 0.81 | NOTUM (0.42) | ALOX5NOTUMMAPTPKMKDM4E | |
| SCHEMBL22164043 | 0.79 | KDM4E (0.49) | NOTUMMAPTKDM4EHSD17B10 | |
| SCHEMBL23526095 | 0.78 | NOTUM (0.41) | KMT2ANOTUMGPR35MAPTPKM | |
| SCHEMBL19138136 | 0.78 | TSHR (0.45) | KMT2AKDM4ETP53TSHR | |
| SCHEMBL29945901 | 0.77 | KMT2A (0.41) | KMT2AMAPTPKMKDM4EHSD17B10 | |
| SCHEMBL23526480 | 0.77 | KMT2A (0.41) | KMT2AMAPTPKMKDM4EHSD17B10 | |
| SCHEMBL23526253 | 0.76 | NR4A2 (0.43) | KMT2AMAPTKDM4EHSD17B10 | |
| SCHEMBL31559525 | 0.76 | NR4A2 (0.43) | KMT2AMAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462626-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-115135315-B | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |