Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | GLS | O94925 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15112849 | 0.91 | CSNK1D (0.70) | LMNAMAPK1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL15113374 | 0.89 | GAA (0.64) | ROCK2LMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL15112848 | 0.88 | LMNA (0.62) | ROCK2LMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL20013893 | 0.87 | ROCK2 (0.60) | ROCK2LMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL20653553 | 0.86 | ROCK2 (0.85) | ROCK2 | |
| SCHEMBL15489027 | 0.84 | CSNK1D (0.69) | LMNASMN1; SMN2CSNK1DMEN1KMT2A | |
| SCHEMBL20408266 | 0.83 | CSNK1D (0.68) | LMNASMN1; SMN2CSNK1DMEN1KMT2A | |
| SCHEMBL15113372 | 0.83 | CSNK1D (0.81) | SMN1; SMN2TSHRMAPK10CSNK1DMAPT | |
| SCHEMBL15112843 | 0.82 | CSNK1D (0.71) | LMNACSNK1DMAPTGAA | |
| SCHEMBL17410545 | 0.82 | GAA (0.64) | LMNAMAPK1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |