SCHEMBL25840770

SCHEMBL25840770

Clc1cccc(CN(Cc2cccc(Cl)c2)Cc2cccc(Cl)c2)c1

nearest known ligand 0.65

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.65
RECQL P46063 1/20 0.65
PNMT P11086 2/20 0.58
PYCR1 P32322 1/20 0.55
TAAR1 Q96RJ0 3/20 0.54
CYP3A4 P08684 2/20 0.52
IDO1 P14902 2/20 0.52
AGXT P21549 2/20 0.52
AOC3 Q16853 1/20 0.50
HTR3E A5X5Y0 3/20 0.48
HTR3B O95264 3/20 0.48
HTR3A P46098 3/20 0.48
HTR3D Q70Z44 3/20 0.48
HTR3C Q8WXA8 3/20 0.48
RIPK1 Q13546 1/20 0.47
CHRM2 P08172 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11530544 0.87 TSHR (0.62) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL2436 0.83
SCHEMBL5733314 0.83 PNMT (0.60) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL29353832 0.83
SCHEMBL30798978 0.82 TAAR1 (0.66) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL8290710 0.82 TAAR1 (0.66) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL10780774 0.82 TSHR (0.56) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL11028540 0.81 PNMT (0.58) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL1001013 0.81 PNMT (0.58) TSHRRECQLPNMTPYCR1TAAR1
SCHEMBL30093221 0.79 PYCR1 (0.67) TSHRRECQLPNMTPYCR1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230382945-A1 THERAPEUTIC AGENTS AND METHODS POP TEST ONCOLOGY LLC (US) 2023-11-30 US disclosed
US-20230382945-A1 THERAPEUTIC AGENTS AND METHODS POP TEST ONCOLOGY LLC (US) 2023-11-30 US disclosed
US-11702443-B2 Therapeutic agents and methods POP TEST ONCOLOGY LLC (US) 2023-07-18 US disclosed
US-11702443-B2 Therapeutic agents and methods POP TEST ONCOLOGY LLC (US) 2023-07-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11702443-B2 Therapeutic agents and methods NR1H4, NR3C1, NR3C2 TSHR 323/4885RECQL 4318/4885PNMT 3089/4885
US-20230382945-A1 THERAPEUTIC AGENTS AND METHODS NR1H4, NR3C1, NR3C2 TSHR 323/4885RECQL 4318/4885PNMT 3089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.