Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16865194 | 0.86 | RET (0.34) | RETRORCTLR9TLR8TLR7 | |
| SCHEMBL18231651 | 0.82 | HSD11B1 (0.39) | — | |
| SCHEMBL16838106 | 0.81 | HSD11B1 (0.44) | RETEPHX2 | |
| SCHEMBL18855653 | 0.80 | HSD11B1 (0.41) | GAA | |
| SCHEMBL18231698 | 0.79 | SPR (0.39) | RORCJAK2JAK1TYK2JAK3 | |
| SCHEMBL22875368 | 0.78 | ALDH1A1 (0.42) | RORCTLR9TLR8TLR7GAA | |
| SCHEMBL3555062 | 0.77 | RET (0.32) | RETTLR9TLR8TLR7JAK2 | |
| SCHEMBL20084013 | 0.77 | HSD11B1 (0.32) | RET | |
| SCHEMBL31732922 | 0.77 | GAA (0.46) | RORCGAA | |
| SCHEMBL15076722 | 0.77 | HSD11B1 (0.44) | TLR9TLR8TLR7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116763-A1 | PYRIDAZINE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海优理惠生医药有限公司 | 2023-06-29 | — | — | WO | disclosed |