Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25443831 | 0.90 | KDM5A (0.47) | ALDH1A1ACKR3HRH3CYP2D6KDM5A | |
| SCHEMBL23798956 | 0.90 | KDM5A (0.47) | ALDH1A1ACKR3HRH3CYP2D6KDM5A | |
| SCHEMBL25443832 | 0.90 | KDM5A (0.47) | ALDH1A1ACKR3HRH3CYP2D6KDM5A | |
| SCHEMBL12719747 | 0.84 | ALDH1A1 (0.50) | ALDH1A1ACKR3HRH3CYP2D6KDM5A | |
| SCHEMBL12413710 | 0.84 | SIGMAR1 (0.45) | ALDH1A1ACKR3KDM5ACYP3A4HPGD | |
| SCHEMBL7088489 | 0.83 | ACKR3 (0.52) | ALDH1A1ACKR3HRH3CYP2D6MAPT | |
| SCHEMBL18199497 | 0.83 | RAB9A (0.49) | KDM5ACYP3A4HPGDCYP2C19RAB9A | |
| SCHEMBL5067337 | 0.83 | RAB9A (0.49) | KDM5ACYP3A4HPGDCYP2C19RAB9A | |
| SCHEMBL13300923 | 0.83 | ALDH1A1 (0.49) | ALDH1A1ACKR3HRH3CYP2D6MAPT | |
| SCHEMBL24712366 | 0.82 | KDM5A (0.40) | ALDH1A1ACKR3HRH3KDM5ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | US | disclosed |
| US-20230233692-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | C4 THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | US | disclosed |
| US-11691972-B2 | Compounds for targeted degradation of BRD9 | C4 THERAPEUTICS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-11673902-B2 | Isoindolinone and indazole compounds for the degradation of EGFR | C4 THERAPEUTICS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | CRBN, CDR2, MDM2 | ALDH1A1 4099/4885ACKR3 3923/4885HRH3 3345/4885 |
| US-20230233692-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | RET, HRAS, RBX1 | ALDH1A1 3400/4885ACKR3 3200/4885HRH3 2249/4885 |
| US-11673902-B2 | Isoindolinone and indazole compounds for the degradation of EGFR | EGFR, ERBB2, ERBB3 | ALDH1A1 2283/4885ACKR3 3126/4885HRH3 2838/4885 |
| US-11691972-B2 | Compounds for targeted degradation of BRD9 | BRD9, BRD1, BRWD1 | ALDH1A1 4230/4885ACKR3 4426/4885HRH3 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.