Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CES2 | O00748 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.54 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935160 | 1.00 | TP53 (0.69) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL5147571 | 0.85 | TSHR (0.70) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL29003219 | 0.85 | CES2 (0.64) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL1694146 | 0.82 | CES2 (0.82) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL15180827 | 0.82 | CES2 (0.82) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL29490968 | 0.82 | TP53 (1.00) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL27709081 | 0.82 | TP53 (1.00) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL132618 | 0.82 | TP53 (1.00) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL14880709 | 0.82 | CES2 (0.69) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL27769205 | 0.81 | ALDH1A1 (0.59) | TP53CES2CES1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107382822-B | Preparation method and product of chalcone containing carbazolyl | 陕西科技大学 | 2020-06-12 | — | — | CN | disclosed |
| US-8048893-B2 | Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them | AVENTIS PHARMA SA (FR) | 2011-11-01 | — | — | US | disclosed |
| US-20090170833-A1 | PYRAZOLYL DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 2009-07-02 | — | — | US | disclosed |
| US-7524838-B2 | Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2009-04-28 | — | — | US | disclosed |
| US-20050165005-A1 | Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2005-07-28 | — | — | US | disclosed |
| EP-0521970-B1 | WATER-INSOLUBLE CYCLODEXTRIN POLYMERIZATES AND PROCESS FOR PRODUCING THEM | CONSORTIUM ELEKTROCHEM IND (DE) | 1995-10-04 | — | — | EP | disclosed |
| US-5324750-A | Coagulation of powdered catalyst; separation | AUSTRALIA COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1994-06-28 | — | — | US | disclosed |
| EP-0431080-A4 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY | — | 1992-10-21 | — | — | EP | disclosed |
| EP-0431080-A1 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY | AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1991-06-12 | — | — | EP | disclosed |
| WO-1990002141-A1 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY | AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1990-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170833-A1 | PYRAZOLYL DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | C1R, CBR3, C3AR1 | TP53 2168/4885CES2 2137/4885CES1 2072/4885 |
| US-20050165005-A1 | Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them | C1R, CBR3, C3AR1 | TP53 2139/4885CES2 2105/4885CES1 2019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.