SCHEMBL8935160

SCHEMBL8935160

C=C(C(=O)O)c1cccc([N+](=O)[O-])c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.69
CES2 O00748 1/20 0.66
CES1 P23141 1/20 0.66
ALDH1A1 P00352 4/20 0.62
TSHR P16473 3/20 0.62
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
PRSS1 P07477 1/20 0.54
PRSS2 P07478 1/20 0.54
PRSS3 P35030 1/20 0.54
MAPT P10636 2/20 0.54
HTT P42858 2/20 0.54
RAB9A P51151 1/20 0.54
MITF O75030 1/20 0.54
HSP90AA1 P07900 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
PTPN1 P18031 1/20 0.54
PTPN12 Q05209 1/20 0.54
PTPN22 Q9Y2R2 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2584445 1.00 TP53 (0.69) TP53CES2CES1ALDH1A1TSHR
SCHEMBL5147571 0.85 TSHR (0.70) TP53CES2CES1ALDH1A1TSHR
SCHEMBL29003219 0.85 CES2 (0.64) TP53CES2CES1ALDH1A1TSHR
SCHEMBL1694146 0.82 CES2 (0.82) TP53CES2CES1ALDH1A1TSHR
SCHEMBL15180827 0.82 CES2 (0.82) TP53CES2CES1ALDH1A1TSHR
SCHEMBL29490968 0.82 TP53 (1.00) TP53CES2CES1ALDH1A1TSHR
SCHEMBL27709081 0.82 TP53 (1.00) TP53CES2CES1ALDH1A1TSHR
SCHEMBL132618 0.82 TP53 (1.00) TP53CES2CES1ALDH1A1TSHR
SCHEMBL14880709 0.82 CES2 (0.69) TP53CES2CES1ALDH1A1TSHR
SCHEMBL27769205 0.81 ALDH1A1 (0.59) TP53CES2CES1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630261-A4 NEW CYCLODEXTRINS AND NEW FORMULATED DRUGS. AUSTRALIAN COMMERCIAL RESEARCH (AU) 1996-11-06 EP disclosed
EP-0521970-B1 WATER-INSOLUBLE CYCLODEXTRIN POLYMERIZATES AND PROCESS FOR PRODUCING THEM CONSORTIUM ELEKTROCHEM IND (DE) 1995-10-04 EP disclosed
EP-0630261-A1 NEW CYCLODEXTRINS AND NEW FORMULATED DRUGS AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1994-12-28 EP disclosed
US-5324750-A Coagulation of powdered catalyst; separation AUSTRALIA COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1994-06-28 US disclosed
WO-1993017711-A1 NEW CYCLODEXTRINS AND NEW FORMULATED DRUGS AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1993-09-16 WO disclosed
EP-0431080-A4 COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY 1992-10-21 EP disclosed
EP-0431080-A1 COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1991-06-12 EP disclosed
WO-1990002141-A1 COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1990-03-08 WO disclosed