Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588879 | 0.81 | HSP90AA1 (0.42) | NPC1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2585772 | 0.81 | TDP1 (0.41) | NPC1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4264818 | 0.81 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1TDP1POLB | |
| SCHEMBL2582036 | 0.79 | GAA (0.52) | NPC1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2586645 | 0.78 | TP53 (0.52) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2585773 | 0.76 | OPRM1 (0.46) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL2588237 | 0.74 | SMN1; SMN2 (0.47) | NPC1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2587258 | 0.74 | KMT2A (0.44) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2581639 | 0.73 | GAA (0.50) | NPC1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5531260 | 0.73 | ALDH1A1 (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |