Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264532 | 0.82 | AKR1C3 (0.50) | APEX1GRM5ALDH1A1KMT2AMEN1 | |
| SCHEMBL2587431 | 0.78 | HSP90AA1 (0.46) | APEX1GRM5ALDH1A1KMT2AHSP90AA1 | |
| SCHEMBL2582036 | 0.76 | GAA (0.52) | SMN1; SMN2ALDH1A1KMT2AHSP90AA1NPC1 | |
| SCHEMBL2578732 | 0.75 | LMNA (0.44) | SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2578646 | 0.75 | HSP90AA1 (0.50) | SMN1; SMN2POLBALDH1A1KMT2AHSP90AA1 | |
| SCHEMBL2582055 | 0.75 | TSHR (0.50) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL5539142 | 0.74 | AKR1C3 (0.46) | ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL2584833 | 0.74 | NPC1 (0.44) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL2585254 | 0.73 | POLB (0.44) | SMN1; SMN2POLBALDH1A1KMT2AHSP90AA1 | |
| SCHEMBL2582179 | 0.72 | RAB9A (0.47) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |