Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25848772 | 0.88 | NPC1 (0.43) | KMT2AMEN1TDP1SMN1; SMN2NPC1 | |
| SCHEMBL25848889 | 0.88 | DDR1 (0.42) | NPC1RAB9ALMNAHDAC1HDAC6 | |
| SCHEMBL25848767 | 0.87 | KMT2A (0.35) | KMT2AMEN1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25848773 | 0.86 | P2RX7 (0.41) | KMT2AMEN1TDP1SMN1; SMN2HDAC1 | |
| SCHEMBL25848757 | 0.86 | HDAC1 (0.44) | RAB9ALMNAHDAC1HDAC6HPGD | |
| SCHEMBL25848766 | 0.84 | RXFP1 (0.47) | KMT2ASMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL25848776 | 0.84 | EPHX2 (0.42) | HDAC1HDAC6 | |
| SCHEMBL25848771 | 0.83 | USP5 (0.36) | KMT2AMEN1TDP1SMN1; SMN2MAPT | |
| SCHEMBL25848775 | 0.81 | MEN1 (0.52) | KMT2AMEN1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL24196134 | 0.80 | P2RX7 (0.43) | KMT2AMEN1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | KMT2A 232/4885MEN1 1117/4885TDP1 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.