Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196676 | 0.88 | NLRP3 (0.43) | MAPTKMT2AHPGDMAOBSMN1; SMN2 | |
| SCHEMBL25848772 | 0.86 | NPC1 (0.43) | RXFP1TP53KMT2ASMN1; SMN2POLB | |
| SCHEMBL25848767 | 0.85 | KMT2A (0.35) | RXFP1MAPTTP53KMT2AMAOB | |
| SCHEMBL25848768 | 0.84 | KMT2A (0.39) | RXFP1MAPTTP53KMT2AHPGD | |
| SCHEMBL25848757 | 0.84 | HDAC1 (0.44) | HPGDLMNAEPHX2 | |
| SCHEMBL25848773 | 0.84 | P2RX7 (0.41) | PDE10AKMT2AHPGDMAOBSMN1; SMN2 | |
| SCHEMBL25848776 | 0.83 | EPHX2 (0.42) | EPHX2 | |
| SCHEMBL25848771 | 0.81 | USP5 (0.36) | RXFP1MAPTTP53KMT2ASMN1; SMN2 | |
| SCHEMBL25848775 | 0.79 | MEN1 (0.52) | MAPTKMT2AHPGDMAOBSMN1; SMN2 | |
| SCHEMBL24196134 | 0.78 | P2RX7 (0.43) | KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | RXFP1 4149/4885MAPT 329/4885TP53 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.