Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852194 | 1.00 | DHFR (0.31) | DHFR | |
| SCHEMBL25852259 | 0.86 | POLRMT (0.36) | DHFR | |
| SCHEMBL18371669 | 0.76 | POLRMT (0.35) | DHFR | |
| SCHEMBL16708502 | 0.76 | POLRMT (0.35) | DHFR | |
| SCHEMBL25852146 | 0.75 | DHFR (0.31) | DHFR | |
| SCHEMBL16708521 | 0.74 | POLRMT (0.34) | — | |
| SCHEMBL18371672 | 0.74 | POLRMT (0.34) | — | |
| SCHEMBL25300989 | 0.69 | POLRMT (0.38) | — | |
| SCHEMBL25254465 | 0.69 | POLRMT (0.38) | — | |
| SCHEMBL25853155 | 0.69 | POLRMT (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697666-B2 | Methods of preparing carbanucleosides using amides | GILEAD SCIENCES, INC. (US) | 2023-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697666-B2 | Methods of preparing carbanucleosides using amides | NCL, DUT, POLN | DHFR 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.