Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504039 | 0.83 | DAO (0.41) | MAPK1KDRLMNAMAPT | |
| SCHEMBL25852152 | 0.81 | DBH (0.41) | KMT2ADBHKDRLMNAPOLB | |
| SCHEMBL20936157 | 0.80 | MAPK14 (0.58) | KDRHTTSMN1; SMN2NPC1CYP2D6 | |
| SCHEMBL25852107 | 0.80 | EGLN1 (0.54) | DBHMAPK1HTTSMN1; SMN2LMNA | |
| SCHEMBL25852271 | 0.79 | KMT2A (0.49) | KMT2AMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL18860580 | 0.78 | DBH (0.43) | KMT2ADBHMAPK1HTTSMN1; SMN2 | |
| SCHEMBL20503971 | 0.77 | FLT1 (0.48) | KMT2AKDRSMN1; SMN2GAACYP1A2 | |
| SCHEMBL25857107 | 0.77 | TP53 (0.37) | KMT2ADBHMEN1POLBMAPT | |
| SCHEMBL20503881 | 0.75 | MAPK14 (0.40) | KMT2ADBHHTTSMN1; SMN2LMNA | |
| SCHEMBL20504077 | 0.75 | MAPK14 (0.37) | KMT2ADBHKDRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023135233-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2023-07-20 | — | — | WO | disclosed |
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |