Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DBH | P09172 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852271 | 0.78 | KMT2A (0.49) | ADORA2AKMT2AMEN1GPR55MAPK14 | |
| SCHEMBL25852199 | 0.77 | KMT2A (0.47) | MAPTKMT2AMEN1POLBDBH | |
| SCHEMBL20503971 | 0.76 | FLT1 (0.48) | KMT2AMAPK14 | |
| SCHEMBL20936157 | 0.76 | MAPK14 (0.58) | TP53ADORA2AMAPK14 | |
| SCHEMBL25853280 | 0.74 | TP53 (0.40) | TP53MAPTADORA2AMAPK14POLB | |
| SCHEMBL25857254 | 0.74 | MAPT (0.42) | TP53MAPTADORA2AKMT2AMEN1 | |
| SCHEMBL29348734 | 0.73 | ACHE (0.48) | TP53MAPTKMT2AMAPK14POLB | |
| SCHEMBL25852152 | 0.73 | DBH (0.41) | TP53MAPTADORA2AKMT2AMAPK14 | |
| SCHEMBL25852518 | 0.73 | MAPT (0.43) | TP53MAPTMAPK14POLBDBH | |
| SCHEMBL25852107 | 0.73 | EGLN1 (0.54) | TP53MAPTMAPK14POLBDBH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |