Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2542830 | 1.00 | CES2 (0.41) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2542831 | 1.00 | CES2 (0.41) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2542824 | 1.00 | CES2 (0.41) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2542827 | 1.00 | CES2 (0.41) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2539283 | 0.90 | L3MBTL1 (0.49) | CES2CES1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL2539279 | 0.90 | L3MBTL1 (0.49) | CES2CES1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL2539280 | 0.90 | L3MBTL1 (0.49) | CES2CES1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL2539276 | 0.90 | L3MBTL1 (0.49) | CES2CES1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL2594258 | 0.84 | ALDH1A1 (0.41) | CES2CES1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL2594255 | 0.84 | ALDH1A1 (0.41) | CES2CES1L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571879-A1 | HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011134877-A1 | HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-03 | — | — | WO | disclosed |