Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | DBH | P09172 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25853512 | 0.83 | KLKB1 (0.44) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL21201593 | 0.78 | MAPT (0.61) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL25852695 | 0.78 | MAPT (0.43) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL1346298 | 0.77 | MAPK14 (0.58) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL21419979 | 0.75 | MAPT (0.49) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL21201592 | 0.75 | MAPT (0.45) | MAPTTP53POLBMAPK14KDM4E | |
| SCHEMBL25857254 | 0.74 | MAPT (0.42) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL4280056 | 0.74 | MAPT (0.43) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL29348734 | 0.74 | ACHE (0.48) | MAPTTP53POLBMAPK14KMT2A | |
| SCHEMBL27383784 | 0.72 | POLB (0.59) | MAPTTP53POLBMAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |