Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DBH | P09172 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852152 | 0.90 | DBH (0.41) | MAPTTP53POLBMAPK14KDM4E | |
| SCHEMBL20503881 | 0.83 | MAPK14 (0.40) | MAPTPOLBMAPK14KDM4EMEN1 | |
| SCHEMBL25853280 | 0.83 | TP53 (0.40) | MAPTTP53POLBMAPK14DBH | |
| SCHEMBL20504077 | 0.83 | MAPK14 (0.37) | MAPTTP53POLBMAPK14KDM4E | |
| SCHEMBL20504056 | 0.82 | MAPK14 (0.40) | MAPTTP53MAPK14NPSR1ADORA2A | |
| SCHEMBL20504049 | 0.80 | MAPT (0.39) | MAPTTP53POLBMAPK14KDM4E | |
| SCHEMBL20504129 | 0.80 | ADRA1D (0.46) | POLBMAPK14KDM4EMEN1KMT2A | |
| SCHEMBL25852107 | 0.79 | EGLN1 (0.54) | MAPTTP53POLBMAPK14KDM4E | |
| SCHEMBL20503999 | 0.79 | P2RX3 (0.39) | MAPTTP53MAPK14ALDH1A1P2RX7 | |
| SCHEMBL20936157 | 0.77 | MAPK14 (0.58) | TP53MAPK14KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |