SCHEMBL2585815

SCHEMBL2585815

COc1nc2c(F)ccc([O])c2c(C)c1Cc1ccc(-n2cccn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.46
RORC P51449 19/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2577124 0.90 PTGDR2 (0.54) PTGDR2RORC
SCHEMBL2581536 0.89 RORC (0.47) RORC
SCHEMBL2573186 0.84 PTGDR2 (0.65) PTGDR2RORC
SCHEMBL2579877 0.84 PTGDR2 (0.46) PTGDR2RORC
SCHEMBL2575061 0.83 PTGDR2 (0.56) PTGDR2RORC
SCHEMBL2574953 0.80 PTGDR2 (0.44) PTGDR2RORC
SCHEMBL2568426 0.76 PTGDR2 (0.62) PTGDR2RORC
SCHEMBL2573527 0.75 PTGDR2 (0.73) PTGDR2RORC
SCHEMBL2570703 0.74 PTGDR2 (0.46) PTGDR2RORC
SCHEMBL2575125 0.73 PTGDR2 (0.52) PTGDR2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2139881-B1 QUINOLINES AND THEIR THERAPEUTIC USE PULMAGEN THERAPEUTICS ASTHMA LTD (GB) 2011-11-09 EP claimed