Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18037995 | 0.93 | NPC1 (0.52) | KMT2ARAB9ANPC1PCTPSMN1; SMN2 | |
| SCHEMBL25858229 | 0.91 | DNM2 (0.45) | KMT2ARAB9ANPC1BLMSMN1; SMN2 | |
| SCHEMBL23258168 | 0.89 | NPC1 (0.51) | KMT2ARAB9ANPC1PCTPSMN1; SMN2 | |
| SCHEMBL18038021 | 0.88 | CNR1 (0.48) | KMT2ARAB9APCTPSMN1; SMN2CNR1 | |
| SCHEMBL18017324 | 0.87 | ALDH1A1 (0.38) | KMT2ANPC1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL25858294 | 0.87 | KMT2A (0.42) | KMT2ARAB9ANPC1BLMSMN1; SMN2 | |
| SCHEMBL23258624 | 0.87 | ALDH1A1 (0.53) | KMT2ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL23258569 | 0.86 | NPC1 (0.54) | KMT2ARAB9ANPC1PCTPSMN1; SMN2 | |
| SCHEMBL25858313 | 0.85 | SMN1; SMN2 (0.47) | KMT2ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL18038000 | 0.85 | KMT2A (0.65) | KMT2ARAB9ANPC1SMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321094-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | Curtana Pharmaceuticals, Inc. | 2023-10-12 | — | — | US | disclosed |
| US-20230271926-A1 | INHIBITION OF OLIG2 ACTIVITY | Curtana Pharmaceuticals, Inc. | 2023-08-31 | — | — | US | disclosed |
| US-11691951-B2 | Inhibition of Olig2 activity | Curtana Pharmaceuticals, Inc. (US) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691951-B2 | Inhibition of Olig2 activity | GLI2, ING2, GMFG | KMT2A 501/4885RAB9A 3638/4885NPC1 4224/4885 |
| US-20230321094-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | PAX2, GLI2, RUNX1 | KMT2A 337/4885RAB9A 4088/4885NPC1 3251/4885 |
| US-20230271926-A1 | INHIBITION OF OLIG2 ACTIVITY | GLI2, ING2, GMFG | KMT2A 501/4885RAB9A 3638/4885NPC1 4224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.