Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 10/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21738049 | 1.00 | HRH3 (0.37) | HRH3SOS1LRRK2 | |
| SCHEMBL21738043 | 1.00 | HRH3 (0.37) | HRH3SOS1LRRK2 | |
| SCHEMBL25858317 | 0.83 | HRH3 (0.38) | HRH3 | |
| SCHEMBL25859539 | 0.72 | RAB9A (0.42) | — | |
| SCHEMBL30644279 | 0.71 | LRRK2 (0.36) | SOS1LRRK2 | |
| SCHEMBL21738060 | 0.71 | HRH3 (0.31) | HRH3 | |
| SCHEMBL30644253 | 0.71 | AKR1C3 (0.47) | HRH3SOS1 | |
| SCHEMBL31276654 | 0.71 | AKR1C3 (0.47) | HRH3SOS1 | |
| SCHEMBL30644271 | 0.69 | AKR1C3 (0.51) | SOS1LRRK2 | |
| SCHEMBL21738058 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702414-B2 | Thiadiazole IRAK4 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702414-B2 | Thiadiazole IRAK4 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702414-B2 | Thiadiazole IRAK4 inhibitors | IRAK4, IRAK3, IRAK1 | HRH3 932/4885SOS1 1295/4885LRRK2 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.