SCHEMBL25859566

SCHEMBL25859566

CCOCOCC#Cc1ccc(-c2nnc(NC)cc2C)c(OCOCC)c1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 2/20 0.32
CACNA2D1 P54289 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25857924 0.89 CACNA2D1 (0.32) NLRP3CACNA2D1
SCHEMBL25859698 0.85 NLRP3 (0.32) NLRP3CACNA2D1
SCHEMBL25301955 0.80 IL1B (0.51) NLRP3
SCHEMBL25256910 0.80 IL1B (0.51) NLRP3
SCHEMBL25861815 0.78
SCHEMBL25859689 0.78 ALDH1A1 (0.37) NLRP3
SCHEMBL25859375 0.76
SCHEMBL30833872 0.73 IL1B (0.53) NLRP3
Iodide SCHEMBL31681896 0.71 NLRP3 (0.40) NLRP3
SCHEMBL30833899 0.71 NLRP3 (0.38) NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131277-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF 药捷安康(南京)科技股份有限公司 2023-07-13 WO disclosed