Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859955 | 0.84 | ALDH1A1 (0.42) | ALDH1A1MAPK1L3MBTL1HRH4HTT | |
| SCHEMBL25859962 | 0.74 | HPGD (0.48) | ALDH1A1L3MBTL1LMNASMN1; SMN2GAA | |
| SCHEMBL19956885 | 0.73 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1HTTLMNA | |
| SCHEMBL23518457 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1HRH4HTT | |
| SCHEMBL7301249 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1HRH4HTT | |
| SCHEMBL24526798 | 0.72 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1HRH4HTT | |
| Hydrochloric Acid SCHEMBL17335911 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1HRH4HTT | |
| SCHEMBL13323438 | 0.71 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1HTTLMNA | |
| SCHEMBL25859798 | 0.71 | ALDH1A1 (0.56) | ALDH1A1HTTLMNASMN1; SMN2MEN1 | |
| SCHEMBL27441071 | 0.71 | PRSS1 (0.69) | ALDH1A1MAPK1L3MBTL1HRH4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212202-A1 | TREATMENT OF MGMT DEFICIENT CANCER WITH 2-FLUOROETHYL-SUBSTITUTED NITROSOUREAS AND OTHER COMPOUNDS | YALE UNIVERSITY | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212202-A1 | TREATMENT OF MGMT DEFICIENT CANCER WITH 2-FLUOROETHYL-SUBSTITUTED NITROSOUREAS AND OTHER COMPOUNDS | MSH2, MGMT, MSH6 | ALDH1A1 227/4885MAPK1 4370/4885L3MBTL1 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.