Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.50 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25860539 | 0.91 | NLRP3 (0.49) | NLRP3CACNA2D1MAPTMAPK1ALDH1A1 | |
| SCHEMBL25300749 | 0.86 | NLRP3 (0.49) | NLRP3CACNA2D1MAPTMAPK1ALDH1A1 | |
| SCHEMBL30488532 | 0.86 | NLRP3 (0.49) | NLRP3CACNA2D1MAPTMAPK1ALDH1A1 | |
| SCHEMBL30488586 | 0.83 | NLRP3 (0.57) | NLRP3MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL25302500 | 0.83 | NLRP3 (0.57) | NLRP3MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL25296656 | 0.83 | CACNA2D1 (0.42) | CACNA2D1MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL25256876 | 0.83 | CACNA2D1 (0.42) | CACNA2D1MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL25862420 | 0.83 | CACNA2D1 (0.42) | CACNA2D1MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL25300817 | 0.82 | GBA1 (0.35) | NLRP3MAPK1ALDH1A1KMT2AHTT | |
| SCHEMBL25300818 | 0.82 | GBA1 (0.35) | NLRP3MAPK1ALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131277-A1 | NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF | 药捷安康(南京)科技股份有限公司 | 2023-07-13 | — | — | WO | disclosed |