Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579176 | 0.89 | SMN1; SMN2 (0.41) | POLBALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2584691 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL4261182 | 0.78 | MEN1 (0.47) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL2587146 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4264547 | 0.73 | KMT2A (0.48) | ALDH1A1KMT2AMEN1GAANPC1 | |
| SCHEMBL2582295 | 0.73 | GAA (0.42) | ALDH1A1KMT2AMEN1USP2SMN1; SMN2 | |
| SCHEMBL2582491 | 0.72 | ALDH1A1 (0.48) | POLBALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2586740 | 0.71 | MAPT (0.53) | POLBALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2578684 | 0.71 | KDM4E (0.42) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL4268544 | 0.70 | CD4 (0.45) | POLBALDH1A1KMT2AHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |