Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587146 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1EGLN1CTSSMEN1 | |
| SCHEMBL2583662 | 0.80 | BCHE (0.47) | EPHX2 | |
| SCHEMBL4260241 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2SCN9AEGLN1MEN1KMT2A | |
| SCHEMBL2586748 | 0.78 | GAA (0.41) | SMN1; SMN2ALDH1A1EGLN1MEN1KMT2A | |
| SCHEMBL2579157 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1EGLN1MEN1KMT2A | |
| SCHEMBL15300377 | 0.75 | CRHBP (0.39) | MEN1KMT2ALIPEEPHX2 | |
| SCHEMBL2582491 | 0.74 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL2578768 | 0.74 | TRPV1 (0.42) | SMN1; SMN2ALDH1A1EGLN1KMT2AMAPT | |
| SCHEMBL5531317 | 0.74 | AKR1C3 (0.43) | SMN1; SMN2SCN9AEGLN1MEN1KMT2A | |
| SCHEMBL2578684 | 0.71 | KDM4E (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |