Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12339940 | 0.88 | KMT2A (0.68) | LMNAHTTALDH1A1USP2POLB | |
| SCHEMBL2588877 | 0.78 | KMT2A (0.54) | LMNAALDH1A1POLBKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2585132 | 0.78 | KMT2A (0.53) | LMNAALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL15088287 | 0.75 | CHRM3 (0.51) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29425141 | 0.75 | CHRM3 (0.47) | CHRM3 | |
| Hydrochloric Acid SCHEMBL29425111 | 0.74 | CHRM3 (0.50) | CHRM3 | |
| Hydrochloric Acid SCHEMBL22615232 | 0.74 | KMT2A (0.40) | LMNAHTTKMT2AMEN1HPGD | |
| SCHEMBL20588691 | 0.72 | RBP4 (0.62) | — | |
| SCHEMBL4339111 | 0.69 | CHRM3 (0.46) | CHRM3 | |
| SCHEMBL2586916 | 0.69 | LMNA (0.57) | LMNAHTTALDH1A1USP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |