Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.47 |
| ▸ | PARG | Q86W56 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25865664 | 0.85 | GRM2 (0.80) | GRM2POLBPARGPIK3CDMAPT | |
| SCHEMBL3365852 | 0.75 | GRIK2 (0.61) | POLBGRIK2GRIK1MAPTSMN1; SMN2 | |
| SCHEMBL19657533 | 0.73 | ALDH1A1 (0.49) | GRM2PARGMAPTSMN1; SMN2KDM4E | |
| SCHEMBL25406024 | 0.72 | ALDH1A1 (0.75) | GRM2ADORA2AADORA2BMAPTSMN1; SMN2 | |
| SCHEMBL19657876 | 0.72 | ALDH1A1 (0.47) | GRM2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL626748 | 0.71 | GRM2 (0.67) | GRM2HPGDKDM4EALDH1A1 | |
| SCHEMBL624936 | 0.71 | GRM2 (0.66) | GRM2PARGPIK3CD | |
| SCHEMBL14992536 | 0.71 | GRM2 (0.69) | GRM2PARGSMN1; SMN2 | |
| SCHEMBL4619699 | 0.71 | BRD4 (0.66) | GRM2POLBMAPTSMN1; SMN2TRIM24 | |
| SCHEMBL30293254 | 0.71 | BRD4 (0.66) | GRM2POLBMAPTSMN1; SMN2TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219938-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PREC MEDICINES INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219938-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | GRM2 222/4885POLB 4342/4885GRIK2 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.