SCHEMBL25865852

SCHEMBL25865852

N#CCCc1ccc(-c2ccc3oc(=O)n(C4COC4)c3c2)cc1F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTSC P53634 4/20 0.39
CTSK P43235 1/20 0.34
CHRM2 P08172 3/20 0.33
CHRM4 P08173 3/20 0.33
CHRM5 P08912 3/20 0.33
CHRM1 P11229 3/20 0.33
CHRM3 P20309 3/20 0.33
FFAR1 O14842 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
PIK3CD O00329 1/20 0.32
ASAH1 Q13510 2/20 0.31
HDAC1 Q13547 2/20 0.30
HDAC6 Q9UBN7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25865847 0.81 CTSC (0.49) CTSCCTSKFFAR1FFAR4ASAH1
SCHEMBL25865853 0.78 CTSC (0.37) CTSCCTSKCHRM2CHRM4CHRM5
SCHEMBL20117054 0.67 CHRM2 (0.53) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL25866149 0.67 CBX7 (0.38) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL26527428 0.64 CTSC (0.46) CTSCASAH1
SCHEMBL24981975 0.63 CTSC (0.56) CTSCCTSK
SCHEMBL28696393 0.63 CTSC (0.56) CTSCCTSK
SCHEMBL31758046 0.62 CTSC (0.44) CTSCCTSK
SCHEMBL29455670 0.61 CTSC (0.49) CTSCCTSKASAH1
SCHEMBL32680807 0.61 CTSC (0.49) CTSCCTSKASAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023134656-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF 上海壹典医药科技开发有限公司 2023-07-20 WO disclosed