Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261756 | 0.83 | GRM5 (0.48) | RAB9ANPC1HSP90AA1LMNAKMT2A | |
| SCHEMBL2587431 | 0.80 | HSP90AA1 (0.46) | GAAALDH1A1HSP90AA1LMNAKMT2A | |
| SCHEMBL2584836 | 0.77 | HSP90AA1 (0.49) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5529310 | 0.76 | GRM5 (0.46) | LMNAGRM5 | |
| SCHEMBL2579235 | 0.73 | HSP90AA1 (0.51) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2586009 | 0.72 | HSP90AA1 (0.53) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2580660 | 0.71 | ALDH1A1 (0.60) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2583226 | 0.71 | ALDH1A1 (0.60) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2588184 | 0.70 | MAPT (0.63) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5526492 | 0.70 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |