SCHEMBL2584836

SCHEMBL2584836

O=C(NCCN1CCCC1)c1noc2c1CN(C(=O)CC1CCCC1)CC2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 8/20 0.49
SMN1; SMN2 Q16637 5/20 0.39
NPC1 O15118 4/20 0.39
RAB9A P51151 4/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
TSHR P16473 2/20 0.39
MAPK1 P28482 1/20 0.39
POLB P06746 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4265989 0.81 ADORA2A (0.43) HSP90AA1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL15300430 0.78 SCD (0.45) HSP90AA1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL2586692 0.77 RAB9A (0.48) HSP90AA1SMN1; SMN2NPC1RAB9ATSHR
SCHEMBL2587431 0.75 HSP90AA1 (0.46) HSP90AA1ALDH1A1GAAKMT2ALMNA
SCHEMBL2579235 0.74 HSP90AA1 (0.51) HSP90AA1SMN1; SMN2NPC1RAB9ATSHR
SCHEMBL2576088 0.73 HSP90AA1 (0.54) HSP90AA1POLBHDAC3HDAC4HDAC1
SCHEMBL2586009 0.73 HSP90AA1 (0.53) HSP90AA1SMN1; SMN2NPC1RAB9APOLB
SCHEMBL2584636 0.73 NPC1 (0.44) HSP90AA1SMN1; SMN2NPC1RAB9ATSHR
SCHEMBL2579191 0.72 POLB (0.48) HSP90AA1SMN1; SMN2NPC1RAB9ATSHR
SCHEMBL5531524 0.72 ADORA2A (0.41) HSP90AA1SMN1; SMN2MAPTADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048879-B2 Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments GRUENENTHAL GMBH (DE) 2011-11-01 US claimed
US-8048879-B2 Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments GRUENENTHAL GMBH (DE) 2011-11-01 US disclosed