Sugi Predict

Sugi Predict / Compounds / SCHEMBL25867906

SCHEMBL25867906

SCHEMBL25867906

CC(C)OCC(N)C(=O)C(C)C

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 2/20 0.33
▸ GABRD O14764 2/20 0.33
▸ GABRA1 P14867 2/20 0.33
▸ GABRB1 P18505 2/20 0.33
▸ GABRG2 P18507 2/20 0.33
▸ GABRB3 P28472 2/20 0.33
▸ GABRA5 P31644 2/20 0.33
▸ GABRA3 P34903 2/20 0.33
▸ GABRA2 P47869 2/20 0.33
▸ GABRB2 P47870 2/20 0.33
▸ GABRA4 P48169 2/20 0.33
▸ GABRE P78334 2/20 0.33
▸ GABRA6 Q16445 2/20 0.33
▸ GABRG1 Q8N1C3 2/20 0.33
▸ GABRG3 Q99928 2/20 0.33
▸ GABRQ Q9UN88 2/20 0.33
▸ SLC7A5 Q01650 1/20 0.33
▸ NOS3 P29474 1/20 0.31
▸ NOS1 P29475 1/20 0.31
▸ NOS2 P35228 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10436302 0.84 SLC7A5 (0.50) SLC7A5NOS3NOS1NOS2SLC1A3
SCHEMBL20932872 0.84 SLC7A5 (0.50) SLC7A5NOS3NOS1NOS2SLC1A3
SCHEMBL722370 0.84 SLC7A5 (0.50) SLC7A5NOS3NOS1NOS2SLC1A3
Hydrochloric Acid SCHEMBL23111921 0.82 SLC7A5 (0.48) SLC7A5NOS3NOS1NOS2SLC1A3
SCHEMBL29292669 0.81 SLC1A3 (0.31) SLC7A5SLC1A3SLC1A2SLC1A1
SCHEMBL14036911 0.79 SLC7A5 (0.34) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL13484493 0.79 NOS3 (0.35) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4445038 0.79 SLC7A5 (0.34) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL15368912 0.79 TSHR (0.35) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL10140610 0.79 NOS3 (0.35) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239828-A1 MANNOSE 6-PHOSPHATE OR ASGPR RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS AVILAR THERAPEUTICS, INC. (US) 2024-07-18 — — US disclosed
US-20240072809-A1 ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS AVILAR THERAPEUTICS, INC. (US) 2024-02-29 — — US disclosed
US-11819551-B2 ASGPR-binding compounds for the degradation of extracellular proteins AVILAR THERAPEUTICS, INC. (US) 2023-11-21 — — US disclosed
US-20230233689-A1 Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins UNIV YALE (US) 2023-07-27 — — US disclosed
US-20230233689-A1 Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins UNIV YALE (US) 2023-07-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11819551-B2 ASGPR-binding compounds for the degradation of extracellular proteins ASGR1, ENGASE, FCGR2A GABRP 1178/4885GABRD 1887/4885GABRA1 1924/4885
US-20230233689-A1 Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins ASGR1, LDLR, FCGR2A GABRP 1582/4885GABRD 2118/4885GABRA1 1531/4885
US-20240239828-A1 MANNOSE 6-PHOSPHATE OR ASGPR RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS M6PR, ASGR1, IGF2R GABRP 1533/4885GABRD 2782/4885GABRA1 2443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.