⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24136291 | 0.82 | PLA2G2C (0.31) | — | |
| SCHEMBL16214300 | 0.77 | THRB (0.34) | — | |
| SCHEMBL14701136 | 0.77 | THRB (0.34) | — | |
| SCHEMBL19541808 | 0.77 | ALDH1A1 (0.34) | — | |
| SCHEMBL16329244 | 0.76 | MEN1 (0.34) | — | |
| SCHEMBL21733117 | 0.75 | HSD17B10 (0.35) | — | |
| SCHEMBL31380117 | 0.75 | HSD17B10 (0.35) | — | |
| SCHEMBL20032308 | 0.74 | TSHR (0.40) | — | |
| SCHEMBL16902771 | 0.74 | LMNA (0.39) | — | |
| SCHEMBL14474311 | 0.74 | PHF8 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | YALE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230271994-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | UNIV YALE (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |