SCHEMBL25869329

SCHEMBL25869329

CC(C(=O)c1ccc2c(c1)OC(CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)C(C)C(=O)c1ccc3c(c1)OCO3)O2)N(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.41
KMT2A Q03164 3/20 0.39
ATM Q13315 1/20 0.39
ALDH1A1 P00352 1/20 0.37
ACE P12821 2/20 0.37
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
CTSS P25774 2/20 0.37
CTSL P07711 2/20 0.37
CTSB P07858 1/20 0.37
CTSK P43235 1/20 0.37
HPGD P15428 1/20 0.36
ROCK2 O75116 2/20 0.36
BACE1 P56817 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25865220 0.89 TAAR1 (0.48) TAAR1KMT2AACETAS1R3TAS1R1
SCHEMBL25865289 0.82 TAS1R3 (0.43) TAAR1KMT2AALDH1A1TAS1R3TAS1R1
SCHEMBL24883800 0.76 ACE (0.47) ALDH1A1ACECTSSCTSLCTSB
SCHEMBL24883920 0.75 ACE (0.35) TAAR1KMT2AATMALDH1A1ACE
SCHEMBL29679318 0.74 ACE (0.50) ATMALDH1A1ACEKDM4ELMNA
SCHEMBL10204542 0.74 ACE (0.50) ATMALDH1A1ACEKDM4ELMNA
SCHEMBL27010613 0.74 ACE (0.50) ATMALDH1A1ACEKDM4ELMNA
SCHEMBL25308745 0.74 TAS1R3 (0.41) TAAR1ALDH1A1TAS1R3TAS1R1KDM4E
SCHEMBL25308744 0.74 TAS1R3 (0.41) TAAR1ALDH1A1TAS1R3TAS1R1KDM4E
SCHEMBL25309930 0.74 TAS1R3 (0.42) TAAR1KMT2AATMALDH1A1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023137453-A1 PRODRUGS OF 3,4-METHYLENEDIOXY-N-METHCATHINONE AND USES THEREOF TERRAN BIOSCIENCES INC. (US) 2023-07-20 WO disclosed