SCHEMBL25870702

SCHEMBL25870702

CN1C(=O)C(=Cc2ccc(N(c3ccccc3)c3ccc(Cl)c4ccccc34)[se]2)C(=O)N(C)C1=S

nearest known ligand 0.32

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.32
MEN1 O00255 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HTT P42858 1/20 0.31
TAAR1 Q96RJ0 1/20 0.31
POLB P06746 1/20 0.30
EP300 Q09472 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25870706 0.94 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870718 0.93 NOX4 (0.31) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870681 0.89 MAPT (0.33) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870724 0.88 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870713 0.86 MEN1 (0.31) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL18863392 0.86 MAPT (0.33) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870717 0.85 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL18863393 0.85 MAPT (0.40) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870729 0.83 LMNA (0.34) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870683 0.83 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11711930-B2 2023-07-25 US disclosed