SCHEMBL25870718

SCHEMBL25870718

Cc1ccc(N(c2ccc(C=C3C(=O)N(C)C(=S)N(C)C3=O)[se]2)c2ccc(Cl)c3ccccc23)cc1

nearest known ligand 0.31

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NOX4 Q9NPH5 1/20 0.31
NOX1 Q9Y5S8 1/20 0.31
MAPT P10636 2/20 0.31
MEN1 O00255 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HTT P42858 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25870706 0.93 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870702 0.93 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870683 0.90 MAPT (0.32) NOX4NOX1MAPTMEN1RAB9A
SCHEMBL25870717 0.87 MAPT (0.32) MAPTMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL25870682 0.87 NOX4 (0.32) NOX4NOX1MAPTMEN1RAB9A
SCHEMBL25870681 0.84 MAPT (0.33) NOX4MAPTMEN1RAB9AKMT2A
SCHEMBL25870688 0.84 MAPT (0.36) NOX4NOX1MAPTMEN1RAB9A
SCHEMBL18863386 0.84 MAPT (0.39) NOX4NOX1MAPTMEN1RAB9A
SCHEMBL25870721 0.83 CISD1 (0.36) NOX4NOX1MAPTMEN1RAB9A
SCHEMBL25870729 0.83 LMNA (0.34) MAPTMEN1RAB9AKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11711930-B2 2023-07-25 US disclosed