SCHEMBL25874690

SCHEMBL25874690

C=CC(=O)Oc1ccc2c(oc3c(C(F)(F)F)c(OC(=O)C=C)ccc32)c1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TYMS P04818 1/20 0.39
THRB P10828 3/20 0.33
THRA P10827 1/20 0.33
CYP2C9 P11712 1/20 0.31
SRD5A1 P18405 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25874023 0.93 TYMS (0.36) TYMS
SCHEMBL25874321 0.92 HPGD (0.39) TYMSTHRBTHRACYP2C9ALDH1A1
SCHEMBL25874702 0.90 TYMS (0.34) TYMSTHRBTHRA
SCHEMBL25874476 0.90 MAOA (0.37) TYMSTHRBTHRACYP2C9ALDH1A1
SCHEMBL25876562 0.88 TYMS (0.35) TYMSTHRBCYP2C9
SCHEMBL25873792 0.87 CYP2C9 (0.40) TYMSTHRBCYP2C9ALDH1A1HSD17B10
SCHEMBL25874695 0.85 THRB (0.37) TYMSTHRBTHRAALDH1A1HPGD
SCHEMBL25876383 0.85 TYMS (0.33) TYMSTHRB
SCHEMBL25876291 0.83 CYP2C9 (0.35) TYMSTHRBCYP2C9ALDH1A1
SCHEMBL25853993 0.79 TYMS (0.36) TYMSTHRBTHRAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023134595-A1 POLYMERIZABLE COMPOUND, COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE 烟台显华科技集团股份有限公司 2023-07-20 WO disclosed
WO-2023134594-A1 NEGATIVE DIELECTRIC ANISOTROPIC LIQUID CRYSTAL COMPOSITION, OPTICAL ANISOTROPIER, AND LIQUID CRYSTAL DISPLAY COMPONENT 烟台显华科技集团股份有限公司 2023-07-20 WO disclosed