Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | PTPRF | P10586 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599576 | 0.80 | KDM4E (0.50) | PDE4DKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL78687 | 0.76 | ACHE (0.53) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL31162811 | 0.76 | ACHE (0.53) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL2591220 | 0.75 | PRF1 (0.50) | PDE4DCYP3A4MAPTALDH1A1LMNA | |
| SCHEMBL6607183 | 0.71 | PDE4D (0.46) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL2591157 | 0.70 | HDAC4 (0.51) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL4110681 | 0.70 | KDM4E (0.57) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL27988062 | 0.68 | ALOX5 (0.56) | CYP3A4MAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL2588301 | 0.67 | PDE4D (0.45) | PDE4DCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL14734712 | 0.65 | KDM4E (0.44) | PDE4DCYP3A4KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | claimed |
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |