Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | GCG | P01275 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | ME2 | P23368 | 1/20 | 0.31 |
| ▸ | ME1 | P48163 | 1/20 | 0.31 |
| ▸ | ME3 | Q16798 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28441262 | 0.83 | HDAC4 (0.42) | MAPTHDAC4EGLN1ALDH1A1GCGR | |
| SCHEMBL30451998 | 0.80 | HDAC4 (0.40) | MAPTHDAC4GCGEGLN1ALDH1A1 | |
| SCHEMBL28435954 | 0.80 | HDAC4 (0.40) | MAPTHDAC4GCGEGLN1ALDH1A1 | |
| SCHEMBL26422895 | 0.79 | HDAC4 (0.46) | MAPTHDAC4GCGALDH1A1KDM4E | |
| SCHEMBL28431647 | 0.75 | TDO2 (0.37) | TDO2EGLN1GRM5ALDH1A1KDM4E | |
| SCHEMBL28938115 | 0.75 | TDO2 (0.37) | TDO2EGLN1GRM5 | |
| SCHEMBL31435193 | 0.75 | HCAR2 (0.39) | TDO2EGLN1GRM5ME2ME1 | |
| SCHEMBL30452646 | 0.75 | TDO2 (0.37) | TDO2EGLN1GRM5ALDH1A1KDM4E | |
| SCHEMBL24921531 | 0.74 | EGLN1 (0.50) | MAPTTDO2EGLN1GRM5KDM4E | |
| SCHEMBL22701706 | 0.74 | EGLN1 (0.50) | TDO2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | TYK MEDICINES, INC. (CN) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | RET, ROR1, FGFR3 | MAPT 1165/4885HDAC4 1603/4885TDO2 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.