SCHEMBL25876408

SCHEMBL25876408

CCC(=O)N1CC2(CCN(C)CC2)C1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
OPRM1 P35372 1/20 0.41
CYP3A4 P08684 6/20 0.40
LMNA P02545 1/20 0.39
CYP2D6 P10635 2/20 0.38
CYP2C19 P33261 1/20 0.38
HSD17B10 Q99714 1/20 0.37
EPHX2 P34913 2/20 0.37
USP2 O75604 1/20 0.37
CYP1A2 P05177 1/20 0.36
HTR1A P08908 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
CHRNB3 Q05901 1/20 0.36
CHRNA6 Q15825 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM1 P11229 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26854526 0.91 ALDH1A1 (0.48) ALDH1A1OPRM1CYP3A4LMNACYP2D6
SCHEMBL15998880 0.89 OPRM1 (0.46) ALDH1A1OPRM1CYP3A4CYP2D6CYP2C19
SCHEMBL25703446 0.88 ALDH1A1 (0.53) ALDH1A1OPRM1CYP3A4LMNACYP2D6
SCHEMBL25870846 0.86 CYP1A2 (0.44) ALDH1A1OPRM1CYP3A4CYP2D6EPHX2
SCHEMBL21765702 0.86 OPRM1 (0.53) ALDH1A1OPRM1CYP3A4LMNACYP2D6
SCHEMBL22802557 0.86 ALDH1A1 (0.59) ALDH1A1OPRM1LMNAEPHX2CHRNB2
SCHEMBL24029694 0.84 ALDH1A1 (0.46) ALDH1A1OPRM1CYP3A4LMNACYP2D6
SCHEMBL15998891 0.82 ALDH1A1 (0.55) ALDH1A1OPRM1CYP3A4LMNACYP2D6
SCHEMBL16127673 0.82 ALDH1A1 (0.55) ALDH1A1OPRM1LMNAEPHX2USP2
SCHEMBL18711512 0.82 ALDH1A1 (0.55) ALDH1A1OPRM1CYP3A4LMNACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023116920-A1 PENTA- FUSED HEXA-HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE 杭州多域生物技术有限公司 2023-06-29 WO disclosed