Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | FABP2 | P12104 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26633277 | 0.81 | LMNA (0.48) | LMNAPTGS1MEN1KMT2AMAPT | |
| SCHEMBL2094710 | 0.79 | CES2 (0.42) | MEN1KMT2AHPGDHTT | |
| SCHEMBL12249542 | 0.77 | PTGS1 (0.43) | LMNAPTGS1MEN1KMT2AMAPT | |
| SCHEMBL1730118 | 0.75 | ALDH1A1 (0.48) | MAPTPTGS2HPGDSMN1; SMN2 | |
| SCHEMBL21586818 | 0.75 | HDAC1 (0.42) | MEN1KMT2AMAPTGAATDP1 | |
| SCHEMBL10269902 | 0.71 | PTGS1 (0.55) | LMNAPTGS1MEN1KMT2AMAPT | |
| SCHEMBL2858939 | 0.71 | ALDH1A1 (0.35) | MEN1KMT2AMAPTGAA | |
| SCHEMBL19185643 | 0.71 | MEN1 (0.41) | LMNAPTGS1MEN1KMT2AMAPT | |
| SCHEMBL2096953 | 0.71 | CES2 (0.43) | — | |
| SCHEMBL9839331 | 0.71 | DHODH (0.41) | MEN1KMT2AMAPTHPGDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137219-A1 | INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) | SCHERING CORPORATION (US) | 2011-11-03 | — | — | WO | disclosed |