Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24140612 | 0.90 | ALDH1A1 (0.51) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9860631 | 0.88 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877366 | 0.88 | ERN1 (0.50) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL24140920 | 0.86 | SMN1; SMN2 (0.50) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877759 | 0.85 | PTPN1 (0.45) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877825 | 0.85 | ERN1 (0.47) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877356 | 0.85 | ERN1 (0.49) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877626 | 0.84 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL25877383 | 0.84 | ERN1 (0.46) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL24140500 | 0.83 | ERN1 (0.50) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | MAPT 3694/4885ALDH1A1 1451/4885SMN1; SMN2 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.