Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25877625 | 0.87 | L3MBTL1 (0.50) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL24140920 | 0.85 | SMN1; SMN2 (0.50) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL25877360 | 0.84 | MAPT (0.52) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL24140940 | 0.84 | ERN1 (0.49) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL25877759 | 0.82 | PTPN1 (0.45) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL24140612 | 0.81 | ALDH1A1 (0.51) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL24140484 | 0.81 | ERN1 (0.49) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL17523247 | 0.80 | MAPT (0.51) | MAPTL3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL9860631 | 0.80 | MAPT (0.50) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL9283599 | 0.78 | MAPT (0.41) | MAPTL3MBTL1SMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | MAPT 3694/4885L3MBTL1 2452/4885SMN1; SMN2 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.