Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77393 | 0.85 | ADRB2 (0.43) | ALDH1A1LMNASMN1; SMN2RECQLGAA | |
| SCHEMBL22897646 | 0.85 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL18147782 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HIF1AVCAM1LMNASMN1; SMN2 | |
| SCHEMBL13077189 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HIF1AVCAM1LMNASMN1; SMN2 | |
| SCHEMBL22897818 | 0.82 | ALDH1A1 (0.35) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4969034 | 0.82 | ALDH1A1 (0.45) | ALDH1A1HIF1AVCAM1LMNASMN1; SMN2 | |
| SCHEMBL19205975 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HIF1AVCAM1LMNASMN1; SMN2 | |
| SCHEMBL20045654 | 0.81 | ALDH1A1 (0.34) | ALDH1A1HIF1ALMNASMN1; SMN2GAA | |
| SCHEMBL6081269 | 0.79 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2GAAMEN1 | |
| SCHEMBL25877846 | 0.77 | MAPT (0.38) | ALDH1A1LMNASMN1; SMN2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | ALDH1A1 1451/4885HIF1A 824/4885VCAM1 3452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.