Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26351569 | 1.00 | SIGMAR1 (0.42) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL25726336 | 0.89 | SIGMAR1 (0.41) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL26351568 | 0.89 | SIGMAR1 (0.41) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL21997855 | 0.89 | SIGMAR1 (0.41) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL29751192 | 0.83 | L3MBTL1 (0.42) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL25726330 | 0.81 | L3MBTL1 (0.47) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL21997469 | 0.81 | L3MBTL1 (0.47) | SIGMAR1TMEM97ITGB3ITGA2BALDH1A1 | |
| SCHEMBL25973768 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL26102752 | 0.79 | L3MBTL1 (0.47) | SIGMAR1TMEM97L3MBTL1HTR2C | |
| SCHEMBL1896919 | 0.78 | ALDH1A1 (0.49) | SIGMAR1ITGB3ITGA2BALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303526-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-09-28 | — | — | US | disclosed |
| US-11707457-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303526-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | SIGMAR1 3199/4885TMEM97 3971/4885ITGB3 3396/4885 |
| US-11707457-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | SIGMAR1 3199/4885TMEM97 3971/4885ITGB3 3396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.