Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29466326 | 1.00 | MEN1 (0.49) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL27180231 | 0.96 | MEN1 (0.45) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL29484593 | 0.91 | CHRNA4 (0.57) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL25883039 | 0.91 | CHRNA4 (0.57) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL25878312 | 0.89 | AURKA (0.49) | MAPTRAB9ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL30864397 | 0.88 | KCNK3 (0.43) | PDE10AKCNK3KCNK9 | |
| SCHEMBL25883037 | 0.88 | KCNK3 (0.43) | PDE10AKCNK3KCNK9 | |
| SCHEMBL25312498 | 0.87 | MAPT (0.53) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL25882715 | 0.87 | MEN1 (0.44) | MEN1MAPTKMT2AKDM4EALPG | |
| SCHEMBL25878265 | 0.85 | MAPT (0.42) | MEN1MAPTKMT2AKDM4EALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215526-A1 | CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2023-07-26 | — | — | EP | disclosed |