Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.55 |
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25879561 | 0.85 | BRAF (0.45) | BRAF | |
| SCHEMBL25879708 | 0.84 | BRAF (0.52) | BRAF | |
| SCHEMBL30512112 | 0.82 | MAP3K5 (0.54) | BRAF | |
| SCHEMBL25879550 | 0.82 | MAP3K5 (0.54) | BRAF | |
| SCHEMBL25879551 | 0.82 | BRAF (0.59) | BRAF | |
| SCHEMBL30512129 | 0.82 | BRAF (0.59) | BRAF | |
| SCHEMBL25880239 | 0.81 | CCNC (0.48) | BRAF | |
| SCHEMBL30512135 | 0.81 | BRAF (0.43) | BRAF | |
| SCHEMBL25879705 | 0.81 | BRAF (0.43) | BRAF | |
| SCHEMBL25882124 | 0.80 | MAP3K5 (0.63) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |