Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 17/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512112 | 0.87 | MAP3K5 (0.54) | CCNCCDK8BRAFMAP3K5 | |
| SCHEMBL25879550 | 0.87 | MAP3K5 (0.54) | CCNCCDK8BRAFMAP3K5 | |
| SCHEMBL25881879 | 0.85 | CDK7 (0.42) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL25881870 | 0.85 | ALDH1A1 (0.41) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL30512101 | 0.85 | CDK7 (0.42) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL25881895 | 0.84 | CREBBP (0.46) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL25879561 | 0.83 | BRAF (0.45) | CCNCCDK8BRAFMAP3K5 | |
| SCHEMBL25880438 | 0.83 | CCNC (0.41) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL25882093 | 0.82 | BRAF (0.37) | CCNCCDK8BRAFMAP3K5CREBBP | |
| SCHEMBL25881893 | 0.82 | BRAF (0.37) | CCNCCDK8BRAFMAP3K5CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |