SCHEMBL25890453

SCHEMBL25890453

CCc1cn(-c2ccc(C(C)CC)cc2)nc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.39
DRD4 P21917 1/20 0.39
DRD3 P35462 1/20 0.39
TSHR P16473 2/20 0.35
ALDH1A1 P00352 2/20 0.35
NPBWR1 P48145 1/20 0.34
MCHR1 Q99705 1/20 0.34
PLA2G7 Q13093 1/20 0.34
MGLL Q99685 1/20 0.34
ABHD6 Q9BV23 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
RXFP1 Q9HBX9 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
ABCB1 P08183 2/20 0.33
P2RX7 Q99572 1/20 0.33
HPGD P15428 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25890532 0.82 MEN1 (0.35) TSHRALDH1A1NPBWR1MCHR1RXFP1
SCHEMBL25890493 0.79 ADORA3 (0.45) DRD2DRD4DRD3ALDH1A1MGLL
SCHEMBL25890613 0.76 NOTUM (0.41) ALDH1A1MGLLSMN1; SMN2RXFP1NPC1
SCHEMBL24359736 0.72 PCSK9 (0.39) TSHRALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL25890691 0.70 MEN1 (0.43) TSHRALDH1A1NPBWR1MCHR1SMN1; SMN2
SCHEMBL13662573 0.69 ALDH1A1 (0.42) TSHRALDH1A1NPBWR1MCHR1HPGD
SCHEMBL598140 0.67 ALDH1A1 (0.52) TSHRALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL10237026 0.67 CYP1A2 (0.53) ALDH1A1NPBWR1MCHR1SMN1; SMN2
SCHEMBL18509374 0.67 NOTUM (0.70) ALDH1A1TDP1
SCHEMBL11990242 0.67 POLB (0.52) DRD2DRD4DRD3ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4198023-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS BASF SE (DE) 2023-06-21 EP disclosed