SCHEMBL25890493

SCHEMBL25890493

CCc1ccc(-n2cc(CC)c(C)n2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.45
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
DRD3 P35462 1/20 0.43
MGLL Q99685 1/20 0.42
POLB P06746 1/20 0.41
SMN1; SMN2 Q16637 4/20 0.40
MAPT P10636 3/20 0.40
GAA P10253 2/20 0.40
HTT P42858 2/20 0.40
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
NPC1 O15118 7/20 0.40
RAB9A P51151 7/20 0.40
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
KDM4E B2RXH2 3/20 0.39
HIF1A Q16665 1/20 0.39
LMNA P02545 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16202084 0.84 NPC1 (0.44) ADORA3DRD2DRD4DRD3MGLL
SCHEMBL25890453 0.79 DRD2 (0.39) DRD2DRD4DRD3MGLLSMN1; SMN2
SCHEMBL25890477 0.78 ADORA3 (0.39) ADORA3DRD2DRD4DRD3MGLL
SCHEMBL2711999 0.73 ALDH1A1 (0.51) POLBSMN1; SMN2NPSR1NPC1RAB9A
SCHEMBL14117962 0.71 RAB9A (0.59) ADORA3DRD2DRD4DRD3SMN1; SMN2
SCHEMBL16201994 0.70 HTT (0.53) ADORA3MGLLPOLBSMN1; SMN2MAPT
SCHEMBL23402380 0.70 NPC1 (0.52) ADORA3POLBSMN1; SMN2MAPTHTT
SCHEMBL16202029 0.69 MEN1 (0.44) ADORA3MGLLPOLBSMN1; SMN2GAA
SCHEMBL26326038 0.69 RXRA (0.47) ADORA3MGLLAPOBEC3GTDP1P2RX7
SCHEMBL28748636 0.69 ADORA3 (0.46) ADORA3SMN1; SMN2MAPTGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4198023-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS BASF SE (DE) 2023-06-21 EP disclosed